2011, ISBN: 9780123851147

The observation that the living cell contains a mechanism to sense and correct the accumulation of unfolded (or incorrectly folded) proteins in the endoplasmic reticulum was formidable in… Plus…

The observation that the living cell contains a mechanism to sense and correct the accumulation of unfolded (or incorrectly folded) proteins in the endoplasmic reticulum was formidable in organizing thoughts about cellular integration. This mechanism both halts further protein synthesis and promotes the production of chaperone proteins that act to relieve this problem. If this problem cannot be corrected, the mechanism can initiate programmed cell death. Aspects of this unfolded protein response (UPR) are conserved from yeast to man, an observation that suggests a key role in the process of maintaining a living cell. The UPR presents a way of understanding cellular regulation, a mechanism for disease and a therapeutic opportunity. This second of three parts provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights. Authors were selected based on research contributions in the area about which they have written and based on their ability to describe their methodological contribution in a clear and reproducible way. They have been encouraged to make use of graphics, comparisons to other methods, and to provide tricks and approaches not revealed in prior publications that make it possible to adapt methods to other systems. The Unfolded Protein Response and Cellular Stress, Part B Buch (fremdspr.) gebundene Ausgabe 01.03.2011 Bücher>Fremdsprachige Bücher>Englische Bücher, Elsevier LTD, Oxford, .201<

2011, ISBN: 9780123851147

[ED: Gebunden], [PU: Elsevier LTD, Oxford], Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Provides descriptions of the occurrence of the… Plus…

[ED: Gebunden], [PU: Elsevier LTD, Oxford], Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact o, DE, [SC: 0.00], Neuware, gewerbliches Angebot, Hardcover, 432, [GW: 858g], New, Banküberweisung, PayPal<

ISBN: 9780123851147

Provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. This… Plus…

Provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. This title explains how these methods are able to provide important biological insights.; Medical & Healthcare Practitioners, Academic Press<

2011, ISBN: 0123851149

Broschiert MEDICAL / General, SCIENCE / Life Sciences / Molecular Biology, mit Schutzumschlag neu, [PU:Elsevier LTD, Oxford]

2011, ISBN: 9780123851147

[ED: 490], 490th edition, Hardcover, Buch, [PU: Academic Press Inc]