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siRNA and miRNA Gene Silencing: From Bench to Bedside - nouveau livre

ISBN: 9781617379086

RNA interference has become a key method in the suppression of gene expression and the development of therapeutic agents, yet there is still the problem of delivery, stability, and the da… Plus…

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RNA interference has become a key method in the suppression of gene expression and the development of therapeutic agents, yet there is still the problem of delivery, stability, and the da… Plus…

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siRNA and miRNA Gene Silencing: From Bench to Bedside - nouveau livre

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RNA interference has become a key method in the suppression of gene expression and the development of therapeutic agents, yet there is still the problem of delivery, stability, and the da… Plus…

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siRNA and miRNA Gene Silencing - nouveau livre

ISBN: 9781617379086

RNA interference has become a key method in the suppression of gene expression and the development of therapeutic agents, yet there is still the problem of delivery, stability, and the da… Plus…

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Mouldy Sioud:
siRNA and miRNA Gene Silencing - Livres de poche

2011, ISBN: 9781617379086

From Bench to Bedside, Buch, Softcover, 1st ed. Softcover of orig. ed. 2009, [PU: Humana Press Inc.], Humana Press Inc., 2011

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siRNA and miRNA Gene Silencing: From Bench to Bedside
Auteur:
Titre:
ISBN:

9781617379086


RNA interference has become a key method in the suppression of gene expression and the development of therapeutic agents, yet there is still the problem of delivery, stability, and the danger of off-target effects such as the silencing of unwanted genes and activation of innate immunity. In siRNA and miRNA Gene Silencing: From Bench to Bedside, expert researchers explore the most recent advances in siRNA design, expression, delivery, in vivo imaging, and methods to minimize siRNA's unwanted effects and promote successful use in patients. As part of the highly successful Methods in Molecular Biology(TM) series, the chapters focus on their respective subjects with easy-to-use, up-to-date information, including several step-by-step laboratory protocols on topics such as new delivery formulations and strategies with promising applications in vitro and in vivo, validated therapeutic target genes, and components of miRNA function, biogenesis, and interference with virus infection.Comprehensive and cutting-edge, siRNA and miRNA Gene Silencing: From Bench to Bedside offers an excellent collection of chapters to aid all those with an interest in RNAi, gene regulation, and new therapies.

Informations détaillées sur le livre - siRNA and miRNA Gene Silencing: From Bench to Bedside


EAN (ISBN-13): 9781617379086
ISBN (ISBN-10): 1617379085
Livre de poche
Date de parution: 2010
Editeur: Humana Press Inc.

Livre dans la base de données depuis 2014-10-10T03:57:35+02:00 (Paris)
Page de détail modifiée en dernier sur 2024-03-10T14:44:24+01:00 (Paris)
ISBN/EAN: 9781617379086

ISBN - Autres types d'écriture:
1-61737-908-5, 978-1-61737-908-6
Autres types d'écriture et termes associés:
Titre du livre: mir

Données de l'éditeur

Auteur: Mouldy Sioud
Titre: Methods in Molecular Biology; siRNA and miRNA Gene Silencing - From Bench to Bedside
Editeur: Humana; Humana Press
472 Pages
Date de parution: 2011-05-26
Totowa; NJ; US
Imprimé / Fabriqué en
Langue: Anglais
160,49 € (DE)
164,99 € (AT)
177,00 CHF (CH)
POD
XIV, 472 p.

BC; Hardcover, Softcover / Biologie/Biochemie, Biophysik; Biochemie; Verstehen; Gene and immunotherapy; Gene regulation; In vivo imaging; RNA interference; Regulation; Small interfering RNA; Telomere; gene expression; genes; microRNA; molecular biology; siRNA expression, design, and delivery; Biochemistry; Medical Genetics; Molecular Genetics; Genetik, Medizin; Genetik (nicht-medizinisch); BB

Methods for Selecting Effective siRNA Sequences by using Statistical and Clustering Techniques.- Deciphering the Code of Innate Immunity Recognition of siRNAs.- Targeted Delivery of Antisense Oligonucleotides and siRNAs into Mammalian Cells.- Local and Systemic Delivery of siRNAs for Oligonucleotides Therapy.- Imaging of siRNA Delivery and Silencing.- Recent Advances in Magnetofection and Its Potential to Deliver siRNAs In Vitro.- In Vitro and In Vivo Gene Silencing by TransKingdom RNAi (tkRNAi).- Bacterial Delivery of siRNAs: A New Approach to Solid Tumor Therapy.- The Therapeutic Potential of LNA-modified siRNAs: Reduction of Off-target Effects by Chemical Modification of the siRNA Sequence.- pSM155 and pSM30 Vectors for miRNA and shRNA Expression.- Targeting Oncogenes with siRNAs.- Targeting Stromal-cancer Cell Interactions with siRNAs.- Therapeutic Potential of siRNA-mediated Targeting of Urokinase Plasminogen Activator, Its Receptor, and Matrix Metalloproteinases.- Silencing of HIF-1#x03B1; by RNA Interference in Human Glioma Cells In Vitro and In Vivo.- RNA Interference-Mediated Validation of Genes Involved in Telomere Maintenance and Evasion of Apoptosis as Cancer Therapeutic Targets.- Treating Respiratory Viral Diseases with Chemically Modified, Second Generation Intranasal siRNAs.- Progress in the Therapeutic Applications of siRNAs Against HIV-1.- Protein Components of the microRNA Pathway and Human Diseases.- Intron-Mediated RNA Interference and microRNA Biogenesis.- Emergence of a Complex Relationship between HIV-1 and the microRNA Pathway.- Synthetic microRNA Targeting Glioma-associated Antigen-1 Protein.- Therapeutic Targeting of Gene Expression by siRNAs Directed Against BCR-ABL Transcripts in a Patient with Imatinib-Resistant Chronic Myeloid Leukemia.
Unparalleled diversity of siRNA delivery and imaging strategies covered in a single volume Details the strategies that predict the design of effective siRNA with minimum side effects Fully explains miRNA biogenesis and how to design microRNA-based vectors and to apply them in vivo Explores the clinical potential of siRNA in human diseases, and describes the first application in patients with cancer

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