ISBN: 9781441932488

In this third edition of Cyhrome P450: Structure, Mechanism, and Biochemistry, Dr. Paul Ortiz de Montellano has brought together a group of new authors as well as authors from previou… Plus…

In this third edition of Cyhrome P450: Structure, Mechanism, and Biochemistry, Dr. Paul Ortiz de Montellano has brought together a group of new authors as well as authors from previous editions to produce a timely volume that will be of considerable interest to a broad array of P450 researchers.The explosion of discovery of CYP (cyhrome P450) genes through genome analysis—more than 3500 to date—provides the more than 10,000 scientists around the world who study these monooxygenases a rich source of interesting and important research problems. Many have remained central elements over the 18 years that span the three editions of this book, including mechanisms of catalysis, oxygen activation and inhibition, gene regulation, and P450 structure. Each new edition updates our knowledge of such central issues in the study of P450s, emphasizing the timeliness of this newest volume.In this newest edition, we find that the newest discussion of P450 structure includes information of bacterial (soluble) P450s interwoven with that of eukaryotic (membrane bound) of this superfamily, highlighting the newest developments in this area. The complete battery of human P450s is now known and summarized in the new edition. In addition, general overviews of plant P450s and those from microbes contained within this newest edition provide a broader view of P450 diversity than seen in earlier editions. Each of these three editions should be on bookshelves of laboratories studying P450s. The third edition of Cyhrome P450: Structure, Mechanism, and Biochemistry provides an opportunity to judge progress in many key areas of P450 research while at the same time learn of new directions in the field. It is an excellent and most useful volume.Dr. Michael R. Waterman, Ph.D., Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TNThe third edition of Cyhrome P450: Structure, Mechanism, and Biochemistry provides an exceptionally fine Textbooks New Books ~~ Medicine~~ Pharmacology Cytochrome-P450~~Paul-R-Ortiz-de-Montellano Springer US The Second Edition reviews the impressive progress that has been made in the last ten years in cytochrome P450 research. Chapters emphasize structure, mechanism, biochemistry, and regulation. This edition offers expanded coverage of P450 crystal structures, site-specific mutagenesis as a probe of structure and function. New chapters explore the hormonal regulation of P450 enzymes, the cytochrome P450-catalyzed oxidation of eicosanoids, human P450 enzymes, and thiolate-ligated hemoproteins other than P450.<

ISBN: 9781441932488

In the ten years that have elapsed since the first edition of this book went to press, the cytochrome P450 field has completed the transition to a discipline in which structure and mechan… Plus…

In the ten years that have elapsed since the first edition of this book went to press, the cytochrome P450 field has completed the transition to a discipline in which structure and mechanism, even regulation and biological function, are dealt with in molecular terms. The twin forces that have propelled this remarkable progress have been the widespread adoption of molecular biological approaches In the ten years that have elapsed since the first edition of this book went to press, the cytochrome P450 field has completed the transition to a discipline in which structure and mechanism, even regulation and biological function, are dealt with in molecular terms. The twin forces that have propelled this remarkable progress have been the widespread adoption of molecular biological approaches and the successful application of modem structural techniques. Only a few P450 primary sequences were available in 1985, whereas hundreds of P450 sequences are now available. Site-specific mutagenesis was then mostly a proverbial gleam in the eye of the P450 community, but it is now a standard technique in the research repertoire. The first crystal structure of a cytochrome P450 enzyme had just been solved in 1985 and appeared on the cover of the first edition. Today, the high-reso- lution crystal structures of four soluble bacterial P450 enzymes are available and the race is on to develop approaches that will permit us to determine the structures of the membrane-bound forms of the enzyme. The past ten years has seen phenomenal progress- let us hope that the next ten will prove equally exciting. The book is informally divided into four sections. In order to hold the book close to the advancing front of research, some of the chapter topics from the first edition have been dropped to make room for new or expanded topics. Books, Medical~~Other Branches of Medicine~~Pharmacology, Cytochrome P450~~Book~~9781441932488, , , , , , , , , ,, [PU: Springer]<

ISBN: 1441932488

Taschenbuch, [EAN: 9781441932488], Springer, Springer, Book, [PU: Springer], Springer, 56087011, Biochemie, 56458011, Biowissenschaften, 56047011, Wissenschaft, 54071011, Genres, 52044011… Plus…

Taschenbuch, [EAN: 9781441932488], Springer, Springer, Book, [PU: Springer], Springer, 56087011, Biochemie, 56458011, Biowissenschaften, 56047011, Wissenschaft, 54071011, Genres, 52044011, Fremdsprachige Bücher, 56560011, Biochemie, 56558011, Grundlagen, 56535011, Medizin, 54071011, Genres, 52044011, Fremdsprachige Bücher, 56687011, Pharmakologie, 56690011, Pharmazie, 56689011, Schmerzmittel, 56691011, Toxikologie, 56535011, Medizin, 54071011, Genres, 52044011, Fremdsprachige Bücher<