Novel Therapeutic Targets for Antiarrhythmic Drugs - nouveau livre

EAN (ISBN-13): 9780470561409
ISBN (ISBN-10): 0470561408
Date de parution: 2010
Editeur: John Wiley & Sons
544 Pages
Langue: eng/Englisch

Livre dans la base de données depuis 2011-01-21T20:19:20+01:00 (Paris)
Page de détail modifiée en dernier sur 2023-03-05T17:19:34+01:00 (Paris)
ISBN/EAN: 9780470561409

ISBN - Autres types d'écriture:
0-470-56140-8, 978-0-470-56140-9
Autres types d'écriture et termes associés:
Auteur du livre: georg edward, bill george

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Données de l'éditeur

Auteur: George Edward Billman
Titre: Novel Therapeutic Targets for Antiarrhythmic Drugs
Editeur: Wiley; John Wiley & Sons
544 Pages
Date de parution: 2010-01-21
Langue: Anglais
165,99 € (DE)
Not available (reason unspecified)

EA; E107; E-Book; Nonbooks, PBS / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Antiarrhythmika; Arzneimittelentwicklung; Cardiovascular Disease; Chemie; Chemistry; Drug Discovery & Development; Kardiovaskuläre Erkrankung; Kardiovaskuläre Erkrankungen; Medical Science; Medizin; Pharmacology & Pharmaceutical Medicine; Pharmakologie u. Pharmazeutische Medizin; Wirkstoffforschung u. -entwicklung; Wirkstoffforschung u. -entwicklung; Kardiovaskuläre Erkrankungen; Pharmakologie u. Pharmazeutische Medizin; BB

Acknowledgments. Contributors. 1. Introduction (George E. Billman). 2. Myocardial K¯+ Channels: Primary Determinants of Action Potential Repolarization (Noriko Niwa and Jeanne Nerbonne). 3. The "Funny" Pacemaker Current (Andrea Barbuti, Annalisa Bucchi, Mirko Baruscotti, and Dario DiFrancesco). 4. Arrhythmia Mechanisms in Ischemia and Infarction (Ruben Coronel, Wen Dun, Penelope A. Boyden, and Jacques M.T. de Bakker). 5. Antiarrhythmic Drug Classification (Cynthia A. Carnes). 6. Repolarization Reserve and Proarrhythmic Risk (András Varró). 7. Safety Challenges in the Development of Novel Antiarrhythmic Drugs (Gary Gintant and Zhi Su). 8. Safety Pharmacology and Regulatory Issues in the Development of Antiarrhythmic Medications (Armando Lagrutta and Joseph J. Salata). 9. Ion Channel Remodeling and Arrhythmias (Takeshi Aiba and Gordon F. Tomaselli). 10. Redox Modification of Ryanodine Receptors in Cardiac Arrhythmia and Failure: A Potential Therapeutic Target (Andriy E. Belevych, Dmitry Terentyev, and Sandor Györke). 11. Targeting Na ¯+ /Ca¯2+ Exchange as an Antiarrhythmic Strategy (Gudrun Antoons, Rik Willems, and Karin R. Sipido). 12. Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII)-Modulation of Ion Currents and Potential Role for Arrhythmias (Dr. Lars S. Maier). 13. Selective Targeting of Ventricular Potassium Channels for Arrhythmia Suppression: Feasible or Risible? (Hugh Clements-Jewery and Michael Curtis). 14. Cardiac Sarcolemmal ATP-sensitive Potassium Channel Antagonists: A Class of Drugs that May Selectively Target the Ischemic Myocardium (George E. Billman). 15. Mitochondrial Origin of Ischemia-Reperfusion Arrhythmias (Brian O'Rourke, PHD). 16. Cardiac Gap Junctions: A New Target for New Antiarrhythmic Drugs: Gap Junction Modulators (Anja Hagen and Stefan Dhein). 17. Novel Pharmacological Targets for the Management of Atrial Fibrillation (Alexander Burashnikov and Charles Antzelevitch). 18. Ikur, Ultra-rapid Delayed Rectifier Potassium Current: A Therapeutic Target for Atrial Arrhythmias (Arun Sridhar and Cynthia A. Carnes). 19. Non-Pharmacologic Manipulation of the Autonomic Nervous System in Human for the Prevention of Life-Threatening Arrhythmias (Peter J. Schwartz). 20. Effects of Endurance Exercise Training on Cardiac Autonomic Regulation and Susceptibility to Sudden Cardiac Death: A Nonpharmacological Approach for the Prevention of Ventricular Fibrillation (George E. Billman). 21. Dietary Omega-3 Fatty Acids as a Nonpharmacological Antiarrhythmic Intervention (Barry London and J. Michael Frangiskakis). General Index. Index of Drug and Chemical Names.