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Guangtao Zhang: Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR : Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator - Livres de poche
2011, ISBN: 3639309693
[EAN: 9783639309690], Nouveau livre, [SC: 10.99], [PU: VDM Verlag Dr. Müller], nach der Bestellung gedruckt Neuware - Printed after ordering - Infectious diseases cause millions of deaths… Plus…
[EAN: 9783639309690], Nouveau livre, [SC: 10.99], [PU: VDM Verlag Dr. Müller], nach der Bestellung gedruckt Neuware - Printed after ordering - Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 M. It could serve as a promising drug to treat cholera. The second project is to use -helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal. 160 pp. Englisch, Books<
Guangtao Zhang: Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Livres de poche
ISBN: 9783639309690
*Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR* - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival… Plus…
*Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR* - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator / Taschenbuch für 58.99 € / Aus dem Bereich: Bücher, Wissenschaft, Chemie Medien > Bücher nein Buch (kartoniert) Hardcover;Naturwissenschaften, Medizin, Informatik, Technik;Organische Chemie, VDM Verlag Dr. Müller<
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Guangtao Zhang: Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Livres de poche
ISBN: 3639309693
Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR ab 58.99 € als Taschenbuch: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulat… Plus…
Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR ab 58.99 € als Taschenbuch: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator. Aus dem Bereich: Bücher, Wissenschaft, Chemie, Medien > Bücher, VDM Verlag Dr. Müller<
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Zhang, Guangtao: Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and ?-Helix Mimetics as Modulators of Dormancy Survival Regulator - Livres de poche
ISBN: 9783639309690
paperback. Good. Access codes and supplements are not guaranteed with used items. May be an ex-library book., 2.5
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR : Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator - Livres de poche
2011, ISBN: 3639309693
[EAN: 9783639309690], Nouveau livre, [SC: 10.99], [PU: VDM Verlag Dr. Müller], nach der Bestellung gedruckt Neuware - Printed after ordering - Infectious diseases cause millions of deaths… Plus…
[EAN: 9783639309690], Nouveau livre, [SC: 10.99], [PU: VDM Verlag Dr. Müller], nach der Bestellung gedruckt Neuware - Printed after ordering - Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 M. It could serve as a promising drug to treat cholera. The second project is to use -helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal. 160 pp. Englisch, Books<
Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Livres de poche
ISBN: 9783639309690
*Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR* - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival… Plus…
*Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR* - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator / Taschenbuch für 58.99 € / Aus dem Bereich: Bücher, Wissenschaft, Chemie Medien > Bücher nein Buch (kartoniert) Hardcover;Naturwissenschaften, Medizin, Informatik, Technik;Organische Chemie, VDM Verlag Dr. Müller<
Frais d'envoiShipping in 1-2 weeks, , Versandkostenfrei nach Hause oder Express-Lieferung in Ihre Buchhandlung., DE. (EUR 0.00)
Guangtao Zhang: Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Livres de poche
ISBN: 3639309693
Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR ab 58.99 € als Taschenbuch: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulat… Plus…
Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR ab 58.99 € als Taschenbuch: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator. Aus dem Bereich: Bücher, Wissenschaft, Chemie, Medien > Bücher, VDM Verlag Dr. Müller<
Zhang, Guangtao: Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR: Development of Bisubstrate Analog Inhibitors of Cholera Toxin and ?-Helix Mimetics as Modulators of Dormancy Survival Regulator - Livres de poche
ISBN: 9783639309690
paperback. Good. Access codes and supplements are not guaranteed with used items. May be an ex-library book., 2.5
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Données bibliographiques du meilleur livre correspondant
Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 µM. It could serve as a promising drug to treat cholera. The second project is to use a-helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal.
Informations détaillées sur le livre - Design Synthesis and Evaluation of Novel Inhibitors of CT and DosR
EAN (ISBN-13): 9783639309690 ISBN (ISBN-10): 3639309693 Version reliée Livre de poche Date de parution: 2011 Editeur: VDM Verlag Dr. Müller
Livre dans la base de données depuis 2009-07-01T15:06:36+02:00 (Paris) Page de détail modifiée en dernier sur 2023-06-25T11:07:36+02:00 (Paris) ISBN/EAN: 3639309693
ISBN - Autres types d'écriture: 3-639-30969-3, 978-3-639-30969-0 Autres types d'écriture et termes associés: Auteur du livre: zhang Titre du livre: synthesis, helix