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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and  -Helix Mimetics as Modulators of Dormancy Survival Regulator - Zhang, Guangtao
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Zhang, Guangtao:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator - Livres de poche

2011, ISBN: 9783639309690

[ED: Taschenbuch / Paperback], [PU: VDM Verlag Dr. Müller], Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 M. It could serve as a promising drug to treat cholera. The second project is to use -helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal., DE, [SC: 0.00], Neuware, gewerbliches Angebot, 160, Selbstabholung und Barzahlung, PayPal, offene Rechnung, Banküberweisung, Interntationaler Versand

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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and  -Helix Mimetics as Modulators of Dormancy Survival Regulator - Zhang, Guangtao
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Zhang, Guangtao:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator - Livres de poche

2011, ISBN: 9783639309690

[ED: Taschenbuch / Paperback], [PU: VDM Verlag Dr. Müller], Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 M. It could serve as a promising drug to treat cholera. The second project is to use -helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal., [SC: 0.00], Neuware, gewerbliches Angebot

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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Guangtao Zhang
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Guangtao Zhang:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - nouveau livre

ISBN: 9783639309690

ID: 0f440a2046809936f6b8dfdbc9c5a185

Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 M. It could serve as a promising drug to treat cholera. The second project is to use -helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal. Bücher / Naturwissenschaften, Medizin, Informatik & Technik / Chemie / Organische Chemie, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR als Buch von Guangtao Zhang - VDM Verlag
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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR als Buch von Guangtao Zhang - nouveau livre

ISBN: 9783639309690

ID: 819609025

Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR ab 58.99 EURO Development of Bisubstrate Analog Inhibitors of Cholera Toxin and a-Helix Mimetics as Modulators of Dormancy Survival Regulator Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR ab 58.99 EURO Development of Bisubstrate Analog Inhibitors of Cholera Toxin and a-Helix Mimetics as Modulators of Dormancy Survival Regulator Bücher > Wissenschaft > Chemie, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR als Buch von Guangtao Zhang - Guangtao Zhang
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Guangtao Zhang:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR als Buch von Guangtao Zhang - edition reliée, livre de poche

ISBN: 9783639309690

ID: 227634691

Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR:Development of Bisubstrate Analog Inhibitors of Cholera Toxin and a-Helix Mimetics as Modulators of Dormancy Survival Regulator Guangtao Zhang Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR:Development of Bisubstrate Analog Inhibitors of Cholera Toxin and a-Helix Mimetics as Modulators of Dormancy Survival Regulator Guangtao Zhang Bücher > Wissenschaft > Chemie, VDM Verlag

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Détails sur le livre
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR

Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 µM. It could serve as a promising drug to treat cholera. The second project is to use a-helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal.

Informations détaillées sur le livre - Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR


EAN (ISBN-13): 9783639309690
ISBN (ISBN-10): 3639309693
Version reliée
Livre de poche
Date de parution: 2011
Editeur: VDM Verlag Dr. Müller

Livre dans la base de données depuis 01.07.2009 15:06:36
Livre trouvé récemment le 01.11.2017 20:29:59
ISBN/EAN: 3639309693

ISBN - Autres types d'écriture:
3-639-30969-3, 978-3-639-30969-0


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