Natural Compounds as Drugs Petersen, Frank und Rene Amstutz: - livre d'occasion

Livre dans la base de données depuis 2008-03-17T06:55:33+01:00 (Paris)
Page de détail modifiée en dernier sur 2023-11-22T21:10:56+01:00 (Paris)
ISBN/EAN: 9783764386269

ISBN - Autres types d'écriture:
3-7643-8626-6, 978-3-7643-8626-9
Autres types d'écriture et termes associés:
Auteur du livre: petersen ernst, jucker, ernst frank, amstütz, rené frank, amstutz peter, ams, frank peters, peter rene
Titre du livre: progress drug research, compounds, drugs, zwei, progres

Données de l'éditeur

Auteur: Frank Petersen; René Amstutz
Titre: Progress in Drug Research; Natural Compounds as Drugs
Editeur: Birkhäuser; Springer Basel
860 Pages
Date de parution: 2008-03-15
Basel; CH
Langue: Anglais
320,99 € (DE)
329,99 € (AT)
354,00 CHF (CH)
Available
860 p. 2 volume-set.

BA; Pharmacology/Toxicology; Hardcover, Softcover / Medizin/Pharmazie; Pharmakologie; Verstehen; Biochemistry, general; Pharmacology; Biochemistry; Biochemie

The use of substances derived from plants, fungi, bacteria and marine organisms has a long tradition in medicine. Together with their derivatives, and synthetic compounds deduced from natural product precursors, they represent a major part of today's pharmaceutical market.

In molecular biological research, natural products also play an important role as tool compounds in pathway screening and validation of target identification concepts. They provide innovative opportunities in drug discovery, leading to a detailed understanding of biological pathways and revealing the functions of involved enzymes or receptors.

This book highlights the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered.

Mother nature's gifts to diseases of man: The impact of natural products on anti-infective, anticholestemics and anticancer drug discovery.- Drug discovery and development with plant-derived compounds.- Evolutionary mechanisms underlying secondary metabolite diversity.- Biodiversity, chemical diversity and drug discovery.- High impact technologies for natural products screening.- Virtual screening for the discovery of bioactive natural products.- Strain improvement for production of pharmaceuticals and other microbial metabolites by fermentation.- Nutritional and engineering aspects of microbial process development.- Natural products from plant cell cultures.

Activation of fungal silent gene clusters: An new avenue to drug discovery.- Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin.- Application of natural product-inspired diversity-oriented synthesis to drug discovery.- Cheminformatics analysis of natural products: Lessons from nature inspiring the design of new drugs.- Chemical-genetic approaches for exploring the mode of action of natural products.- Epothilones as lead structures for new anticancer drugs – pharmacology, fermentation, and structure-activity-relationships.- Histone deacetylase inhibitors from microorganisms: the Astellas experience.- Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720.- Artemisinin – an innovative cornerstone for anti-malaria therapy

The use of drug substances derived from plants, fungi, bacteria, and marine organisms has a long tradition in medicine. Together with their derivatives, and synthetic compounds deduced from natural product precursors, they represent a major part of today's pharmaceutical market.

Within the fast developing discipline of molecular biology, natural products also play an important role as tool compounds in pathway screening and validation of target identification concepts. They provide innovative opportunities in drug discovery, leading to a detailed understanding of biological pathways and revealing the functions of involved enzymes or receptors.

This book highlights new trends and aspects in natural products research. It discusses the biodiversity-driven approaches which are now of eminent importance in natural products research, addressing the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered.

Highlights innovative opportunities in drug discovery

Overview of strategies and screening methods

Compilation of current applicable technology