2009, ISBN: 9783639164732

[ED: Taschenbuch / Paperback], [PU: VDM Verlag Dr. Müller], The nicotinic acetylcholine receptor (AChR) is a pentameric ligand-gated ion channel that can switch between ion-impermeable (c… Plus…

[ED: Taschenbuch / Paperback], [PU: VDM Verlag Dr. Müller], The nicotinic acetylcholine receptor (AChR) is a pentameric ligand-gated ion channel that can switch between ion-impermeable (closed) and ion-permeable (open) conformations. The transition state structures that link the closed and open states are largely unresolved. In this study, I used single-molecule kinetic analysis and rate-equilibrium linear free energy relationships (REFERs) to obtain information about the transition state of the gating reaction and elucidate the sequence of molecular events between the closed and open conformational states. REFER analyses of 87 mutants in the M4 transmembrane segments indicate that the M4 segment moves as single domain and in the middle of the gating reaction, with both subunits moving synchronously. Between the subunits, the sequence of M4 motions is . In the pore-lining M2 segments, I show that the two -subunits experience distinct energy barriers to gating at the equator and that the subunit motions in this region are asymmetric with regard to their reaction progress in the AChR gating conformational 'wave'. Future experiments involving a more extensive REFER analysis will provide finer details of this ion channel nanomachine., DE, [SC: 0.00], Neuware, gewerbliches Angebot, 172, [GW: 235g], Selbstabholung und Barzahlung, PayPal, Offene Rechnung, Banküberweisung, Internationaler Versand<

2009, ISBN: 9783639164732

[ED: Softcover], [PU: VDM Verlag Dr. Müller], The nicotinic acetylcholine receptor (AChR) is a pentameric ligand-gated ion channel that can switch between ion-impermeable (closed) and ion… Plus…

[ED: Softcover], [PU: VDM Verlag Dr. Müller], The nicotinic acetylcholine receptor (AChR) is a pentameric ligand-gated ion channel that can switch between ion-impermeable (closed) and ion-permeable (open) conformations. The transition state structures that link the closed and open states are largely unresolved. In this study, I used single-molecule kinetic analysis and rate-equilibrium linear free energy relationships (REFERs) to obtain information about the transition state of the gating reaction and elucidate the sequence of molecular events between the closed and open conformational states. REFER analyses of 87 mutants in the M4 transmembrane segments indicate that the M4 segment moves as single domain and in the middle of the gating reaction, with both subunits moving synchronously. Between the subunits, the sequence of M4 motions is . In the pore-lining M2 segments, I show that the two -subunits experience distinct energy barriers to gating at the equator and that the subunit motions in this region are asymmetric with regard to their reaction progress in the AChR gating conformational 'wave'. Future experiments involving a more extensive REFER analysis will provide finer details of this ion channel nanomachine. 2009. 172 S. Versandfertig in 6-10 Tagen, DE, [SC: 0.00], Neuware, gewerbliches Angebot, Offene Rechnung (Vorkasse vorbehalten)<

ISBN: 9783639164732

*Gating Nanodomains of the Acetylcholine Receptor* - Single-channel Transition State Analysis of the Transmembrane Segments / Taschenbuch für 67.99 € / Aus dem Bereich: Bücher, Wissenscha… Plus…

*Gating Nanodomains of the Acetylcholine Receptor* - Single-channel Transition State Analysis of the Transmembrane Segments / Taschenbuch für 67.99 € / Aus dem Bereich: Bücher, Wissenschaft, Biologie Medien > Bücher nein Buch (kartoniert) Hardcover;Naturwissenschaften, Medizin, Informatik, Technik;Biochemie, Biophysik, VDM Verlag Dr. Müller<

2009, ISBN: 9783639164732

VDM Verlag, Taschenbuch, 172 Seiten, Publiziert: 2009-07-01T00:00:01Z, Produktgruppe: Book, Ingenieurwissenschaft & Technik, Naturwissenschaften & Technik, Kategorien, Bücher, Biophysik, … Plus…

VDM Verlag, Taschenbuch, 172 Seiten, Publiziert: 2009-07-01T00:00:01Z, Produktgruppe: Book, Ingenieurwissenschaft & Technik, Naturwissenschaften & Technik, Kategorien, Bücher, Biophysik, Biologie, Biowissenschaften, VDM Verlag, 2009<

2009, ISBN: 3639164733

[EAN: 9783639164732], Neubuch, [PU: VDM Verlag], New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000