Prodrugs and Targeted Delivery - edition reliée, livre de poche

EAN (ISBN-13): 9783527326037
ISBN (ISBN-10): 3527326030
Version reliée
Date de parution: 2010
Editeur: Rautio, Jarkko, Wiley-VCH
496 Pages
Poids: 1,104 kg
Langue: eng/Englisch

Livre dans la base de données depuis 2007-01-16T12:28:29+01:00 (Paris)
Page de détail modifiée en dernier sur 2023-09-23T10:37:34+02:00 (Paris)
ISBN/EAN: 9783527326037

ISBN - Autres types d'écriture:
3-527-32603-0, 978-3-527-32603-7
Autres types d'écriture et termes associés:
Auteur du livre: kubinyi, rauti, raimund, hugo, wiley vch, gerd folkers
Titre du livre: delivery beyond, principles chemistry

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Données de l'éditeur

Auteur: Jarkko Rautio
Titre: Methods and Principles in Medicinal Chemistry; Prodrugs and Targeted Delivery - Towards Better ADME Properties
Editeur: Wiley-VCH; Wiley-VCH
496 Pages
Date de parution: 2010-12-15
Imprimé / Fabriqué en
Poids: 1,432 kg
Langue: Anglais
185,00 € (DE)
190,20 € (AT)
Available
170mm x 240mm x 39mm

BB; Hardcover, Softcover / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Verstehen; Medizin, Gesundheit; Arzneimittelentwicklung; Arzneimittelforschung; Chemie; Chemistry; Drug Discovery & Development; Drug Formulation & Delivery; Toxicology; Toxikologie; Wirkstoff; Wirkstoffformulierung, Wirkstofftransport; Wirkstoffforschung u. -entwicklung; Wirkstoffforschung u. -entwicklung; Wirkstoffformulierung, Wirkstofftransport; Toxikologie

By definition, drugs are highly active substances that are beneficial if they act at the right time and in the right place, but can cause harm otherwise. A clever strategy to ensure that a drug only becomes active when needed is to "camouflage" it. Such camouflaged, i.e. deactivated, drugs that become chemically or biochemically activated once they reach their site of action are called prodrugs. This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies, beginning at the early stages of the development process, while also discussing organ- and site-selective prodrugs. From the contents: * Prodrug design and intellectual property * Prodrugs addressing ADMET issues * Codrugs and soft drugs * Preclinical and clinical consideration for prodrugs This book is a valuable reference for all companies employing medicinal chemists by giving a practice-oriented overview of a key strategy in modern drug discovery and development.