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Enhancement of solubility of Mebendazole by SEDDS | Self Emulsifying Drug Delivery System of Mebendazole with improved solubility, effective against lymphatic filariasis | Naveen Patel (u. a.) | Buch - Patel, Naveen
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Enhancement of solubility of Mebendazole by SEDDS | Self Emulsifying Drug Delivery System of Mebendazole with improved solubility, effective against lymphatic filariasis | Naveen Patel (u. a.) | Buch - Livres de poche

2012, ISBN: 9783659116339

[ED: Taschenbuch], [PU: LAP Lambert Academic Publishing], The aim of the present work was to prepare Self emulsifying drug delivery system (SEDDS) of a lipophilic drug, Mebendazole for in… Plus…

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Enhancement of solubility of Mebendazole by SEDDS / Self Emulsifying Drug Delivery System of Mebendazole with improved solubility, effective against lymphatic filariasis / Naveen Patel (u. a.) / Buch - Patel, Naveen
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Enhancement of solubility of Mebendazole by SEDDS / Self Emulsifying Drug Delivery System of Mebendazole with improved solubility, effective against lymphatic filariasis / Naveen Patel (u. a.) / Buch - Livres de poche

2012, ISBN: 9783659116339

[ED: Taschenbuch], [PU: LAP Lambert Academic Publishing], The aim of the present work was to prepare Self emulsifying drug delivery system (SEDDS) of a lipophilic drug, Mebendazole for in… Plus…

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Enhancement of solubility of Mebendazole by SEDDS - Livres de poche

2012

ISBN: 3659116335

[EAN: 9783659116339], Neubuch, [PU: LAP LAMBERT Academic Publishing], MEDIZIN PHARMAZIE MEBENDAZOLE SELF EMULSIFYING DRUG DELIVERY TOCOPHEROL ACETATE PEG 200 LABRASOL, Dieser Artikel ist … Plus…

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Enhancement of solubility of Mebendazole by SEDDS: Self Emulsifying Drug Delivery System of Mebendazole with improved solubility, effective against lymphatic filariasis - Livres de poche

2012, ISBN: 9783659116339

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Enhancement of solubility of Mebendazole by SEDDS: Self Emulsifying Drug Delivery System of Mebendazole with improved solubility, effective against lymphatic filariasis

The aim of the present work was to prepare Self emulsifying drug delivery system (SEDDS) of a lipophilic drug, Mebendazole for increasing its solubility. Various oils, surfactants and co-surfactants were screened for their suitability in the formulation of SEDDS. Based on the initial screening, Omix of Tocopherol acetate and Peceol in the ratio 6:4 and surfactant, Labrasol and co-surfactant, PEG 200 were found to be satisfactory. Five formulations were selected from pseudoternary phase diagrams and were evaluated for parameters like drug content, percentage transmittance, dilution potential, centrifugation test, in-vitro release study, emulsification time and dispersibility, emulsion droplet size, zeta potential, polydispersibility index and ex-vivo permeation studies. All the formulations exhibited a rapid emulsification rate and a good polydispersibity index. The size of the droplets as determined by zeta sizer was found to be below 300 nm. The percentage drug release from the formulations was improved compared to that of pure drug. Thus, the formulated SEDDS helped in improving the solubility and dissolution of the drug, thereby increasing its therapeutic effectiveness.

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EAN (ISBN-13): 9783659116339
ISBN (ISBN-10): 3659116335
Version reliée
Livre de poche
Date de parution: 2012
Editeur: LAP LAMBERT Academic Publishing

Livre dans la base de données depuis 2008-12-03T11:42:46+01:00 (Paris)
Page de détail modifiée en dernier sur 2023-11-08T21:02:57+01:00 (Paris)
ISBN/EAN: 3659116335

ISBN - Autres types d'écriture:
3-659-11633-5, 978-3-659-11633-9
Autres types d'écriture et termes associés:
Auteur du livre: patel, lanka
Titre du livre: solubilities, enhancement, solubility


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