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Enhancement of solubility of Mebendazole by SEDDS: Self Emulsifying Drug Delivery System of Mebendazole with improved solubility, effective against lymphatic filariasis - Naveen Patel, Aparna Lanka
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Naveen Patel, Aparna Lanka:
Enhancement of solubility of Mebendazole by SEDDS: Self Emulsifying Drug Delivery System of Mebendazole with improved solubility, effective against lymphatic filariasis - Livres de poche

ISBN: 3659116335

[SR: 4877339], Paperback, [EAN: 9783659116339], LAP LAMBERT Academic Publishing, LAP LAMBERT Academic Publishing, Book, [PU: LAP LAMBERT Academic Publishing], LAP LAMBERT Academic Publishing, The aim of the present work was to prepare Self emulsifying drug delivery system (SEDDS) of a lipophilic drug, Mebendazole for increasing its solubility. Various oils, surfactants and co-surfactants were screened for their suitability in the formulation of SEDDS. Based on the initial screening, Omix of Tocopherol acetate and Peceol in the ratio 6:4 and surfactant, Labrasol and co-surfactant, PEG 200 were found to be satisfactory. Five formulations were selected from pseudoternary phase diagrams and were evaluated for parameters like drug content, percentage transmittance, dilution potential, centrifugation test, in-vitro release study, emulsification time and dispersibility, emulsion droplet size, zeta potential, polydispersibility index and ex-vivo permeation studies. All the formulations exhibited a rapid emulsification rate and a good polydispersibity index. The size of the droplets as determined by zeta sizer was found to be below 300 nm. The percentage drug release from the formulations was improved compared to that of pure drug. Thus, the formulated SEDDS helped in improving the solubility and dissolution of the drug, thereby increasing its therapeutic effectiveness., 265544, Pharmacology, 16311581, Cardiovascular, 16311631, Chemistry, 16311601, Clinical, 16311591, Drug Delivery Systems, 227673, Drug Guides, 227661, For Nurses, 227738, For Veterinarians, 16311541, Molecular, 16311571, Neuropsychopharmacology, 265547, Pain Medicine, 16311561, Pharmacodynamics, 265548, Pharmacy, 16311611, Product Development, 16311551, Reference, 265549, Toxicology, 173514, Medical Books, 1000, Subjects, 283155, Books

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Enhancement of solubility of Mebendazole by SEDDS: Self Emulsifying Drug Delivery System of Mebendazole with improved solubility, effective against lymphatic filariasis - Naveen Patel, Aparna Lanka
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Naveen Patel, Aparna Lanka:
Enhancement of solubility of Mebendazole by SEDDS: Self Emulsifying Drug Delivery System of Mebendazole with improved solubility, effective against lymphatic filariasis - Livres de poche

2012, ISBN: 3659116335

Paperback, [EAN: 9783659116339], LAP LAMBERT Academic Publishing, LAP LAMBERT Academic Publishing, Book, [PU: LAP LAMBERT Academic Publishing], 2012-06-23, LAP LAMBERT Academic Publishing, 270945, Pharmacology, 270906, Other Branches of Medicine, 270767, Medical & Healthcare Practitioners, 74, Health, Family & Lifestyle, 1025612, Subjects, 266239, Books, 922572, Medical Sciences A-Z, 922574, Accident & Emergency Medicine, 270911, Anaesthetics, 270844, Cardiovascular, 922594, Clinical Psychology & Psychotherapy, 922596, Counselling & Therapy, 922606, Dermatology, 922610, Diseases & Disorders, 922632, Elderly Care, 270864, Endocrinology, 922638, ENT, 270928, Forensic Medicine, 270867, Gastroenterology, 922654, Health Psychology, 922664, Neurology, 922676, Ophthalmology, 922678, Orthopaedic & Fractures, 922682, Paediatrics, 922684, Pathology, 922700, Pre-clinical Medicine, 270948, Psychiatry, 922718, Psychotherapy & Clinical Psychology, 922720, Public Health & Preventive Medicine, 922730, Radiology & Medical Imaging, 270889, Renal Medicine, 270890, Respiratory Medicine, 270891, Rheumatology, 922752, Sports Injuries & Medicine, 922754, Surgery, 270892, Urology, 922532, Medicine, 57, Science & Nature, 1025612, Subjects, 266239, Books, 571382, Medical Sciences A-Z, 571384, Anaesthetics, 571400, Cardiovascular, 571334, Diseases & Disorders, 571390, Gynaecology & Obstetrics, 571386, Neurology, 571316, Orthopaedic & Fractures, 571388, Paediatrics, 571362, Pathology, 571392, Psychiatry, 571290, Public Health & Preventive Medicine, 571350, Radiology & Medical Imaging, 571280, Research & Equipment, 571310, Surgery, 564356, Medicine & Nursing, 564334, Scientific, Technical & Medical, 1025612, Subjects, 266239, Books

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Enhancement of Solubility of Mebendazole by Sedds (Paperback) - Naveen Patel
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Enhancement of Solubility of Mebendazole by Sedds (Paperback) - Livres de poche

2012, ISBN: 3659116335

ID: 14611016122

[EAN: 9783659116339], Neubuch, [PU: LAP Lambert Academic Publishing, Germany], Language: English . Brand New Book ***** Print on Demand *****.The aim of the present work was to prepare Self emulsifying drug delivery system (SEDDS) of a lipophilic drug, Mebendazole for increasing its solubility. Various oils, surfactants and co-surfactants were screened for their suitability in the formulation of SEDDS. Based on the initial screening, Omix of Tocopherol acetate and Peceol in the ratio 6:4 and surfactant, Labrasol and co-surfactant, PEG 200 were found to be satisfactory. Five formulations were selected from pseudoternary phase diagrams and were evaluated for parameters like drug content, percentage transmittance, dilution potential, centrifugation test, in-vitro release study, emulsification time and dispersibility, emulsion droplet size, zeta potential, polydispersibility index and ex-vivo permeation studies. All the formulations exhibited a rapid emulsification rate and a good polydispersibity index. The size of the droplets as determined by zeta sizer was found to be below 300 nm. The percentage drug release from the formulations was improved compared to that of pure drug. Thus, the formulated SEDDS helped in improving the solubility and dissolution of the drug, thereby increasing its therapeutic effectiveness.

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Enhancement of solubility of Mebendazole by SEDDS: Self Emulsifying Drug Delivery System of Mebendazole with improved solubility, effective against lymphatic filariasis - Naveen Patel, Aparna Lanka
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Naveen Patel, Aparna Lanka:
Enhancement of solubility of Mebendazole by SEDDS: Self Emulsifying Drug Delivery System of Mebendazole with improved solubility, effective against lymphatic filariasis - Livres de poche

2012, ISBN: 9783659116339

ID: 615203948

LAP LAMBERT Academic Publishing, 2012-06-23. Paperback. Good., LAP LAMBERT Academic Publishing, 2012-06-23

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Enhancement of Solubility of Mebendazole by Sedds - Patel, Naveen, and Lanka, Aparna
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Patel, Naveen, and Lanka, Aparna:
Enhancement of Solubility of Mebendazole by Sedds - Livres de poche

2012, ISBN: 9783659116339

ID: 12284766989

Trade paperback, New., Trade paperback (US). Glued binding. 104 p. Black & white illustrations., [PU: LAP Lambert Academic Publishing]

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Détails sur le livre
Enhancement of solubility of Mebendazole by SEDDS

The aim of the present work was to prepare Self emulsifying drug delivery system (SEDDS) of a lipophilic drug, Mebendazole for increasing its solubility. Various oils, surfactants and co-surfactants were screened for their suitability in the formulation of SEDDS. Based on the initial screening, Omix of Tocopherol acetate and Peceol in the ratio 6:4 and surfactant, Labrasol and co-surfactant, PEG 200 were found to be satisfactory. Five formulations were selected from pseudoternary phase diagrams and were evaluated for parameters like drug content, percentage transmittance, dilution potential, centrifugation test, in-vitro release study, emulsification time and dispersibility, emulsion droplet size, zeta potential, polydispersibility index and ex-vivo permeation studies. All the formulations exhibited a rapid emulsification rate and a good polydispersibity index. The size of the droplets as determined by zeta sizer was found to be below 300 nm. The percentage drug release from the formulations was improved compared to that of pure drug. Thus, the formulated SEDDS helped in improving the solubility and dissolution of the drug, thereby increasing its therapeutic effectiveness.

Informations détaillées sur le livre - Enhancement of solubility of Mebendazole by SEDDS


EAN (ISBN-13): 9783659116339
ISBN (ISBN-10): 3659116335
Version reliée
Livre de poche
Date de parution: 2012
Editeur: Lap Lambert Academic Publishing Jun 2012

Livre dans la base de données depuis 03.12.2008 11:42:46
Livre trouvé récemment le 18.11.2017 16:27:10
ISBN/EAN: 3659116335

ISBN - Autres types d'écriture:
3-659-11633-5, 978-3-659-11633-9


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