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Molecular Mechanisms Of Nitroglycerin Bioactivation - Matteo Beretta
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Matteo Beretta:
Molecular Mechanisms Of Nitroglycerin Bioactivation - nouveau livre

ISBN: 9783639063325

ID: a67cedb73ed55330d22ebd66d96b0f28

New findings about GTN-derived nitric oxide formation Nitroglycerin (GTN) is used to treat cardiovascular diseases, as it is believed to act through NO release. Although GTN is considered safe, its continuous administration results in a complete loss of hemodynamic effects (nitrate tolerance), probably due to increased oxidative stress or impaired metabolism, leading to lower NO bioavailability in vasculature. ALDH2 seems to be the key enzyme of GTN bioactivation, although the reaction mechanism is still elusive. This work shows (i) direct NO formation during ALDH2-catalyzed reaction, suggesting 3-electron GTN reduction yielding NO beside 2-electron reduction yielding nitrite; (ii) ALDH2 inactivation during GTN metabolism and its partial restoration by thiols; (iii) co-generation of superoxide, which limits NO bioavailability and might explain nitrate tolerance; (iv) association between ascorbate deficiency-caused nitrate tolerance in guinea pigs and reduced ALDH2 activity; (v) GTN reduction to NO also by cytosolic ALDH1; (vi) non-enzymatic GTN bioactivation by ascorbate; (vii) lack of involvement of the mitochondrial respiratory chain in GTN bioactivation. Bücher / Fremdsprachige Bücher / Englische Bücher 978-3-639-06332-5, VDM Verlag

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Molecular Mechanisms Of Nitroglycerin Bioactivation - Matteo Beretta
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Matteo Beretta:
Molecular Mechanisms Of Nitroglycerin Bioactivation - nouveau livre

ISBN: 9783639063325

ID: 179685679

Nitroglycerin (GTN) is used to treat cardiovascular diseases, as it is believed to act through NO release. Although GTN is considered safe, its continuous administration results in a complete loss of hemodynamic effects (nitrate tolerance), probably due to increased oxidative stress or impaired metabolism, leading to lower NO bioavailability in vasculature. ALDH2 seems to be the key enzyme of GTN bioactivation, although the reaction mechanism is still elusive. This work shows (i) direct NO formation during ALDH2-catalyzed reaction, suggesting 3-electron GTN reduction yielding NO beside 2-electron reduction yielding nitrite; (ii) ALDH2 inactivation during GTN metabolism and its partial restoration by thiols; (iii) co-generation of superoxide, which limits NO bioavailability and might explain nitrate tolerance; (iv) association between ascorbate deficiency-caused nitrate tolerance in guinea pigs and reduced ALDH2 activity; (v) GTN reduction to NO also by cytosolic ALDH1; (vi) non-enzymatic GTN bioactivation by ascorbate; (vii) lack of involvement of the mitochondrial respiratory chain in GTN bioactivation. New findings about GTN-derived nitric oxide formation Buch (fremdspr.) Bücher>Fremdsprachige Bücher>Englische Bücher, VDM Verlag

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MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION - Beretta, Matteo
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Beretta, Matteo:
MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION - Livres de poche

2010, ISBN: 9783639063325

[ED: Softcover], [PU: Vdm Verlag Dr. Müller], Nitroglycerin (GTN) is used to treat cardiovascular diseases, as it is believed to act through NO release. Although GTN is considered safe, its continuous administration results in a complete loss of hemodynamic effects (nitrate tolerance), probably due to increased oxidative stress or impaired metabolism, leading to lower NO bioavailability in vasculature. ALDH2 seems to be the key enzyme of GTN bioactivation, although the reaction mechanism is still elusive. This work shows (i) direct NO formation during ALDH2-catalyzed reaction, suggesting 3-electron GTN reduction yielding NO beside 2-electron reduction yielding nitrite (ii) ALDH2 inactivation during GTN metabolism and its partial restoration by thiols (iii) co-generation of superoxide, which limits NO bioavailability and might explain nitrate tolerance (iv) association between ascorbate deficiency-caused nitrate tolerance in guinea pigs and reduced ALDH2 activity (v) GTN reduction to NO also by cytosolic ALDH1 (vi) non-enzymatic GTN bioactivation by ascorbate (vii) lack of involvement of the mitochondrial respiratory chain in GTN bioactivation.2010. 200 S.Versandfertig in 3-5 Tagen

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MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION als Buch von Matteo Beretta - VDM Verlag
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MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION als Buch von Matteo Beretta - nouveau livre

ISBN: 9783639063325

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MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION ab 67.99 EURO New findings about GTN-derived nitric oxide formation MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION ab 67.99 EURO New findings about GTN-derived nitric oxide formation Bücher > Wissenschaft > Medizin, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION - Beretta, Matteo
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MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION - Livres de poche

2010, ISBN: 3639063325

ID: 13788052820

[EAN: 9783639063325], Neubuch, This item is printed on demand for shipment within 3 working days., [PU: VDM Verlag Dr. Müller, Saarbrücken]

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MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION: New findings about GTN-derived nitric oxide formation

Nitroglycerin (GTN) is used to treat cardiovascular diseases, as it is believed to act through NO release. Although GTN is considered safe, its continuous administration results in a complete loss of hemodynamic effects (nitrate tolerance), probably due to increased oxidative stress or impaired metabolism, leading to lower NO bioavailability in vasculature. ALDH2 seems to be the key enzyme of GTN bioactivation, although the reaction mechanism is still elusive. This work shows (i) direct NO formation during ALDH2-catalyzed reaction, suggesting 3-electron GTN reduction yielding NO beside 2-electron reduction yielding nitrite; (ii) ALDH2 inactivation during GTN metabolism and its partial restoration by thiols; (iii) co-generation of superoxide, which limits NO bioavailability and might explain nitrate tolerance; (iv) association between ascorbate deficiency-caused nitrate tolerance in guinea pigs and reduced ALDH2 activity; (v) GTN reduction to NO also by cytosolic ALDH1; (vi) non-enzymatic GTN bioactivation by ascorbate; (vii) lack of involvement of the mitochondrial respiratory chain in GTN bioactivation.

Informations détaillées sur le livre - MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION: New findings about GTN-derived nitric oxide formation


EAN (ISBN-13): 9783639063325
ISBN (ISBN-10): 3639063325
Version reliée
Livre de poche
Date de parution: 2010
Editeur: VDM Verlag
200 Pages
Poids: 0,314 kg
Langue: eng/Englisch

Livre dans la base de données depuis 19.08.2008 19:23:41
Livre trouvé récemment le 16.10.2017 10:41:24
ISBN/EAN: 3639063325

ISBN - Autres types d'écriture:
3-639-06332-5, 978-3-639-06332-5


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