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Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide - Novartis Foundation
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Novartis Foundation:
Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide - nouveau livre

ISBN: 9780470057667

ID: 3bbc2984abd419bf7e0f35a7bc943049

Acetaldehyde Related Pathology brings together contributions from experts working on all aspects of acetaldehyde related pathology in order to better understand the pathogenesis of diseases in which acetaldehyde, from whichever source, is implicated. Acetaldehyde contributes to pathologies ranging from cancer to asthma. It affects the whole body, the architecture of the cell and molecular control mechanisms. The origins of acetaldehyde vary from bacteria in the oral cavity and intestinal tract to atmospheric acetaldehyde as an environmental pollutant. Significant amounts of acetaldehyde are also derived from cigarette smoke and alcohol, both of which are major contributors to disease globally. Acetaldehyde has deleterious effects in the liver, brain and skeletal muscle. It has also been shown that bacteria can generate significant amounts of acetaldehyde in the gastrointestinal tract, thus contributing to carcinogenesis in this tissue. Many of the toxic effects of ethanol ingestion are mediated through acetaldehyde and there is increasing awareness that acetaldehyde is a principal disease-forming agent in tobacco-related illnesses. Alcohol is metabolized by conversion to acetaldehyde, which in turn is converted to acetate by aldehyde dehydrogenase (ALDH). There are a number of forms of ALDH of which the mitochondrial isoform (ALDH2) is particularly important. The ALDH2 gene has a functional polymorphism: homozygous subjects have little or no ALDH2 activity compared to their wild-type counterparts. Heterozygotes generally also have low ALDH2 activity. Epidemiological studies have found increased risk of certain diseases, including cancer of the gastrointestinal tract, alcoholic liver disease and late-onset Alzheimer's disease in subjects with ALDH2 deficiency. This book features contributions from researchers working on all aspects of acetaldehyde-related pathology. From their expert accounts and the lively discussions accompanying each chapter, we can derive a better understanding of the pathogenesis of diseases in which acetaldehyde, from whichever source, is implicated. Bücher / Fremdsprachige Bücher / Englische Bücher 978-0-470-05766-7, Wiley John + Sons

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Novartis Foundation:
Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide - nouveau livre

ISBN: 9780470057667

ID: 165009737

Acetaldehyde contributes to pathologies ranging from cancer to asthma. It affects the whole body, the architecture of the cell and molecular control mechanisms. The origins of acetaldehyde vary from bacteria in the oral cavity and intestinal tract to atmospheric acetaldehyde as an environmental pollutant. Significant amounts of acetaldehyde are also derived from cigarette smoke and alcohol, both of which are major contributors to disease globally. Acetaldehyde has deleterious effects in the liver, brain and skeletal muscle. It has also been shown that bacteria can generate significant amounts of acetaldehyde in the gastrointestinal tract, thus contributing to carcinogenesis in this tissue. Many of the toxic effects of ethanol ingestion are mediated through acetaldehyde and there is increasing awareness that acetaldehyde is a principal disease-forming agent in tobacco-related illnesses. Alcohol is metabolized by conversion to acetaldehyde, which in turn is converted to acetate by aldehyde dehydrogenase (ALDH). There are a number of forms of ALDH of which the mitochondrial isoform (ALDH2) is particularly important. The ALDH2 gene has a functional polymorphism: homozygous subjects have little or no ALDH2 activity compared to their wild-type counterparts. Heterozygotes generally also have low ALDH2 activity. Epidemiological studies have found increased risk of certain diseases, including cancer of the gastrointestinal tract, alcoholic liver disease and late-onset Alzheimer´s disease in subjects with ALDH2 deficiency. This book features contributions from researchers working on all aspects of acetaldehyde-related pathology. From their expert accounts and the lively discussions accompanying each chapter, we can derive a better understanding of the pathogenesis of diseases in which acetaldehyde, from whichever source, is implicated. Acetaldehyde Related Pathology brings together contributions from experts working on all aspects of acetaldehyde related pathology in order to better understand the pathogenesis of diseases in which acetaldehyde, from whichever source, is implicated. Buch (fremdspr.) Bücher>Fremdsprachige Bücher>Englische Bücher, Wiley John + Sons

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Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide - nouveau livre

ISBN: 9780470057667

ID: 978047005766

Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived from ingested alcohol, amongst other sources. In the body, acetaldehyde affects several tissues, particularly the brain and liver, causing various diseases, including cancer, alcoholic liver disease and Alzheimer’s. Acetaldehyde-Related Pathology describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of alcohol dehydrogenase mutants, and the cell-signalling pathways implicated in alcohol-related pathology. It explores the mechanisms of acetaldehyde-induced damage to tissues, often a first step in carcinogenesis, including the oral cavity, the human airway, and the GI tract. The book considers pharmacological strategies and treatments for reducing oral and intestinal acetaldehyde. Acetaldehyde-Related Pathology features in-depth, round-table discussions by an international array of scientists from major laboratories worldwide involved in studies of acetaldehyde-related pathology. This book is essential reading for anyone interested in the effects of this compound - pathologists, biochemists, toxicologists, cell and molecular biologists. Novartis Novartis Foundation, Books, Health and Well Being, Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide Books>Health and Well Being, Wiley

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ISBN: 9780470057667

ID: 1504709

Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived from ingested alcohol, amongst other sources. In the body, acetaldehyde affects several tissues, particularly the brain and liver, causing various diseases, including cancer, alcoholic liver disease and Alzheimer's. "Acetaldehyde-Related Pathology" describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of alcohol dehydrogenase mutants, and the cell-signalling pathways implicated in alcohol-related pathology. It explores the mechanisms of acetaldehyde-induced damage to tissues, often a first step in carcinogenesis, including the oral cavity, the human airway, and the GI tract. The book considers pharmacological strategies and treatments for reducing oral and intestinal acetaldehyde. "Acetaldehyde-Related Pathology" features in-depth, round-table discussions by an international array of scientists from major laboratories worldwide involved in studies of acetaldehyde-related pathology. This book is essential reading for anyone interested in the effects of this compound - pathologists, biochemists, toxicologists, cell and molecular biologists. Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide Novartis Foundation, John Wiley & Sons

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Acetaldehyde-Related Pathology - edition reliée, livre de poche

2007, ISBN: 9780470057667

ID: 7748148

Hardcover, Buch, [PU: Wiley-Blackwell]

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Détails sur le livre
Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide
Auteur:

Novartis Foundation

Titre:

Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide

ISBN:

Acetaldehyde contributes to pathologies ranging from cancer to asthma. It affects the whole body, the architecture of the cell and molecular control mechanisms. The origins of acetaldehyde vary from bacteria in the oral cavity and intestinal tract to atmospheric acetaldehyde as an environmental pollutant. Significant amounts of acetaldehyde are also derived from cigarette smoke and alcohol, both of which are major contributors to disease globally. Acetaldehyde has deleterious effects in the liver, brain and skeletal muscle. It has also been shown that bacteria can generate significant amounts of acetaldehyde in the gastrointestinal tract, thus contributing to carcinogenesis in this tissue. Many of the toxic effects of ethanol ingestion are mediated through acetaldehyde and there is increasing awareness that acetaldehyde is a principal disease-forming agent in tobacco-related illnesses. Alcohol is metabolized by conversion to acetaldehyde, which in turn is converted to acetate by aldehyde dehydrogenase (ALDH). There are a number of forms of ALDH of which the mitochondrial isoform (ALDH2) is particularly important. The ALDH2 gene has a functional polymorphism: homozygous subjects have little or no ALDH2 activity compared to their wild-type counterparts. Heterozygotes generally also have low ALDH2 activity. Epidemiological studies have found increased risk of certain diseases, including cancer of the gastrointestinal tract, alcoholic liver disease and late-onset Alzheimer's disease in subjects with ALDH2 deficiency. This book features contributions from researchers working on all aspects of acetaldehyde-related pathology. From their expert accounts and the lively discussions accompanying each chapter, we can derive a better understanding of the pathogenesis of diseases in which acetaldehyde, from whichever source, is implicated.

Informations détaillées sur le livre - Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide


EAN (ISBN-13): 9780470057667
ISBN (ISBN-10): 0470057661
Version reliée
Date de parution: 2007
Editeur: John Wiley & Sons
275 Pages
Poids: 0,585 kg
Langue: eng/Englisch

Livre dans la base de données depuis 27.05.2008 01:41:52
Livre trouvé récemment le 09.04.2017 02:15:28
ISBN/EAN: 0470057661

ISBN - Autres types d'écriture:
0-470-05766-1, 978-0-470-05766-7


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