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Hormesis: A Revolution in Biology, Toxicology and Medicine
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Hormesis: A Revolution in Biology, Toxicology and Medicine - nouveau livre

ISBN: 9781607614944

ID: 978160761494

Hormesis is defined as any circumstance in which exposure of a cell or organism to a low dose of a substance or condition results in an adaptive stimulatory/beneficial outcome, while exposure to a high dose results in an inhibitory / detrimental outcome. When plotted on a graph the shape of the dose response curve is biphasic, the hallmark of hormesis. This groundbreaking book Hormesis: A Revolution in Biology, Toxicology and Medicine describes why and how hormesis is a fundamental feature of all living systems and is based on the evolutionary principle of selection for genetic traits that confer the ability to respond adaptively to adverse environmental conditions. Using numerous specific examples the authors explain why knowledge of hormesis is important for our health, our environment, and the future of our planet. Several chapters of the book describe emerging research findings that elucidate the molecular and cellular underpinnings of the biphasic dose response/hormesis. The implications of the tapping of cellular systems that underlie hormesis for the discovery and optimization of new drugs and dietary formulations are described. From environmental protection policy to medical practice, it is critical that leaders recognize and understand hormesis, and incorporate it into their decision making process. The authors propose that the prevention of major diseases, including diabetes, obesity and cardiovascular disease can be achieved using hormetic approaches. Scientists, physicians, environmental gurus and anyone interested in the science underlying biology and medicine will benefit from reading this book.FeaturesGroundbreaking coverage of an oft experienced, but poorly understood phenomenon that affects all forms of life on earth.Explains why the principle of hormesis is important to our health, our environment, and the future of our planet. Provides specific examples of biphasic dose responses and their importance for the fields of biology, medicine and environmental safety.Discusses how knowledge of hormesis is being applied to research aimed understanding the organization and function of biological systems.Illustrates how disorders such as diabetes, obesity and cardiovascular disease result from the lack of exposure to beneficial environmental stresses. Considers the implications of the cellular systems that underlie hormesis for the discovery and optimization of new drugs and dietary formulations. Books, Health and Well Being, Hormesis: A Revolution in Biology, Toxicology and Medicine Books>Health and Well Being, Humana Press

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Hormesis
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Hormesis - nouveau livre

2008, ISBN: 9781607614944

ID: 9615035

The term hormesis is de?ned as "a process in which exposure to a low dose of a chemical agent or environmental factor that is damaging at higher doses induces an adaptive bene?cial effect on the cell or organism" (Calabrese et al, 2007; Mattson, 2008). To survive and reproduce in harsh competitive environments, organisms and their cellular components have, through evolution, developed. The term hormesis is de?ned as "a process in which exposure to a low dose of a chemical agent or environmental factor that is damaging at higher doses induces an adaptive bene?cial effect on the cell or organism" (Calabrese et al, 2007; Mattson, 2008). To survive and reproduce in harsh competitive environments, organisms and their cellular components have, through evolution, developed molecular mec- nisms to respond adaptively to various hazards or "stressors" that they encounter. Examples of such stressors include chemicals ingested in food and water (metals, phytochemicals, etc.), increased energy expenditure (running, ?ghting, cognitive challenges, etc.), and reduced energy availability (food scarcity), among others. In most cases, the response of the cell or organism to the stressor exhibits a biphasic dose response, with bene?cial/adaptive responses at low doses (improved fu- tion, increased resistance to damage and disease) and adverse/destructive effects (dysfunction, molecular damage, or even death) at high doses. The prevalence of the biphasic (hormetic) dose response characteristic of biological systems merits consideration of hormesis as a fundamental principle of biology. Books, Medical~~Pre-Clinical Medicine: Basic Sciences~~Physiology, Hormesis~~Book~~9781607614944, , , , , , , , , ,

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Hormesis - Mark P. Mattson#Edward J. Calabrese
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Mark P. Mattson#Edward J. Calabrese:
Hormesis - nouveau livre

ISBN: 9781607614944

ID: 018f115a36a7e79851835e6f2f6f8596

Hormesis is a poorly understood phenomenon affecting all forms of life on earth. This groundbreaking book summarizes and analyzes the various positives of hormesis in an attempt to reveal hormesis as a fundamental principle of biomedical sciences as a whole. PThis book stems from the belief that scientists and policy makers should be guided by the most reliable predictive models available, among which the hormetic dose response model has considerable evidence to support it, is very generalizable, has a strong mechanistic foundation and can be applied in the assessment of single agents and complex mixtures. For these reasons, the hormetic model should become the default in risk assessment./P PThis book summarizes and analyzes the various positives of hormesis in an attempt to revel hormesis as a fundamental principle of toxicology, biology, and biomedical sciences as a whole. A focused discussion of how acceptance of the hormedis based model of toxicology would affect environmental standards and clean up values is mounted. A panel of scientists has been recruited to critically evaluate the hormetic dose response model and its comparison with current default models in their individual fields, including cellular biology, evolutionary biology, gerontology, and pharmacology. In-depth investigations are provided into how biological systems respond to increasing doses of environmental toxins while attempting to understand how cells respond to stress in the contexts of aging and neurological disorders./P Bücher / Fremdsprachige Bücher / Englische Bücher 978-1-60761-494-4, Humana Press

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Hormesis - Mark P. Mattson#Edward J. Calabrese
Livre non disponible
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Mark P. Mattson#Edward J. Calabrese:
Hormesis - nouveau livre

ISBN: 9781607614944

ID: 29494218

PThis book stems from the belief that scientists and policy makers should be guided by the most reliable predictive models available, among which the hormetic dose response model has considerable evidence to support it, is very generalizable, has a strong mechanistic foundation and can be applied in the assessment of single agents and complex mixtures. For these reasons, the hormetic model should become the default in risk assessment./P PThis book summarizes and analyzes the various positives of hormesis in an attempt to revel hormesis as a fundamental principle of toxicology, biology, and biomedical sciences as a whole. A focused discussion of how acceptance of the hormedis based model of toxicology would affect environmental standards and clean up values is mounted. A panel of scientists has been recruited to critically evaluate the hormetic dose response model and its comparison with current default models in their individual fields, including cellular biology, evolutionary biology, gerontology, and pharmacology. In-depth investigations are provided into how biological systems respond to increasing doses of environmental toxins while attempting to understand how cells respond to stress in the contexts of aging and neurological disorders./P Hormesis is a poorly understood phenomenon affecting all forms of life on earth. This groundbreaking book summarizes and analyzes the various positives of hormesis in an attempt to reveal hormesis as a fundamental principle of biomedical sciences as a whole. Buch (fremdspr.) Bücher>Fremdsprachige Bücher>Englische Bücher, Humana Press

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Hormesis - Mattson, Mark P. / Calabrese, Edward J. (Hrsg.)
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Mattson, Mark P. / Calabrese, Edward J. (Hrsg.):
Hormesis - edition reliée, livre de poche

2009, ISBN: 9781607614944

[ED: Hardcover], [PU: Springer, Berlin Humana Press], This book stems from the belief that scientists and policy makers should be guided by the most reliable predictive models available, among which the hormetic dose response model has considerable evidence to support it, is very generalizable, has a strong mechanistic foundation and can be applied in the assessment of single agents and complex mixtures. For these reasons, the hormetic model should become the default in risk assessment. This book summarizes and analyzes the various positives of hormesis in an attempt to revel hormesis as a fundamental principle of toxicology, biology, and biomedical sciences as a whole. A focused discussion of how acceptance of the hormedis based model of toxicology would affect environmental standards and clean up values is mounted. A panel of scientists has been recruited to critically evaluate the hormetic dose response model and its comparison with current default models in their individual fields, including cellular biology, evolutionary biology, gerontology, and pharmacology. In-depth investigations are provided into how biological systems respond to increasing doses of environmental toxins while attempting to understand how cells respond to stress in the contexts of aging and neurological disorders. 2009. xiv, 213 S. 7 Tabellen. 240 mm Versandfertig in 3-5 Tagen, Neuware, gewerbliches Angebot

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Détails sur le livre
Hormesis
Auteur:

Mark P. Mattson

Titre:

Hormesis

ISBN:

1607614944

This book stems from the belief that scientists and policy makers should be guided by the most reliable predictive models available, among which the hormetic dose response model has considerable evidence to support it, is very generalizable, has a strong mechanistic foundation and can be applied in the assessment of single agents and complex mixtures. For these reasons, the hormetic model should become the default in risk assessment.This book summarizes and analyzes the various positives of hormesis in an attempt to revel hormesis as a fundamental principle of toxicology, biology, and biomedical sciences as a whole. A focused discussion of how acceptance of the hormedis based model of toxicology would affect environmental standards and clean up values is mounted. A panel of scientists has been recruited to critically evaluate the hormetic dose response model and its comparison with current default models in their individual fields, including cellular biology, evolutionary biology, gerontology, and pharmacology. In-depth investigations are provided into how biological systems respond to increasing doses of environmental toxins while attempting to understand how cells respond to stress in the contexts of aging and neurological disorders.

Informations détaillées sur le livre - Hormesis


EAN (ISBN-13): 9781607614944
ISBN (ISBN-10): 1607614944
Version reliée
Date de parution: 2009
Editeur: Springer-Verlag GmbH
208 Pages
Poids: 0,530 kg
Langue: eng/Englisch

Livre dans la base de données depuis 10.08.2007 00:01:37
Livre trouvé récemment le 05.11.2016 18:53:29
ISBN/EAN: 1607614944

ISBN - Autres types d'écriture:
1-60761-494-4, 978-1-60761-494-4

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